| Meet the University of Wisconsin-Madison’s Matthew E. Brown Assistant Professor of Surgery |
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Research area Exploring the nexus of pluripotent stem cell (PSC) biology and immunology and investigating the mechanisms underpinning the immune response to autologous and allogeneic PSC-derived cell therapies. Research uses transplantation immunology, genomics-based strategies and humanized mouse models to improve traditional organ transplantation outcomes, gain new insights into PSC biology and immunology, and enable curative regenerative medicine therapies.
What excites you about your work?
“Knowing that what we’re doing in the lab could one day help patients–improve or save their lives–that is the motivating factor, and it is always in the back of our minds. Right now, I’m most excited about hypoimmune gene editing. We’ve developed a new gene edit to protect cell therapies from being recognized by a recipient’s immune system. We study transplantation immunology and PSC biology, so we designed this edit using our immunology expertise to be a new class of next-generation approach that hasn’t been done yet.”
What do you hope to achieve?
“A goal of mine is to conduct clinical trials with these stem cell therapies–I’d love to be part of the first therapeutic PSC clinical trial in Wisconsin using hypoimmune therapies developed in our lab. UW-Madison is a great university for stem cell research. In addition to a number of leading research labs being here, we also have top-notch infrastructure and institutional expertise for conducting clinical trials; it is a real asset to the state of Wisconsin.”
The results of Matt’s research bring novel solutions to some of the entangled issues in applying stem cell technologies to human health. Matt collaborates with industry, to bring the best chance of success in application of his discoveries.
Want to learn more?
Jennifer Gottwald, [email protected], 608.960.9854