Wisconsin Alumni Research Foundation

Technology

PHOTO-CLEAVABLE SURFACTANTS

UW-Madison researchers have developed photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded ...
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Ying Ge, Song Jin, Tania Guardado Alvarez, Kyle Brown | P180335US03

Technology

Kras Conditional Knockout Allele

Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
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Jing Zhang | P210181US01

Technology

Planar High-Speed Molecule Sequencer

A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01

Technology

Nanopore Antennas for Ultrahigh Speed DNA Sequencing

‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01

Technology

Computer-Based Determination of Haplotype

Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US

Technology

DNA Sequencing with Piezoelectric Nanopore

‘Nanopore sequencing’ holds the potential for sequencing a single molecule of DNA without the need for conventional tools like chemical labels or costly optical instruments. This promising method ...
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Robert Blick, Eric Stava | P130036US01

Technology

Efficient Whole Genome Analysis System

In addition to simple nucleotide polymorphisms, the human genome includes intermediate structural variations, such as amplifications, insertions, deletions, inversions and complex rearrangements. Whil...
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David Schwartz, Konstantinos Potamousis, Shiguo Zhou, Steven Goldstein, Michael Newton, Rodney Runnheim, Daniel Forrest, Christopher Churas | P07298US

Technology

Markerless Gene Replacement Plasmids for E. coli

Microbial genome sequencing projects uncover large numbers of new genes. Functional analyses of these genes require targeted modifications of particular DNA sequences in their chromosomal locations us...
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Frederick Blattner, Gyorgy Posfai, Vitaliy Kolisnychenko, Zsuzsa Bereczki | P01153US

WARF