Research into new therapies for skin diseases is challenging for a number of reasons. As is known, skin cells are exposed to both atmospheric air and liquids within the body. However, conventional cel...
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Liquid handling is a critical step in biological assays and typically includes either a reagent addition or solution exchange process. However, it’s challenging to manipulate samples on the microsca...
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Lumens are tubular structures pervasive throughout all body systems. Typical in vitro cell models used by pharmaceutical industries lack the dimensional complexity necessary to mimic lumen structures ...
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Wildfires occur naturally in many ecosystems worldwide; however, the frequency of wildfires has increased in recent years. The United States National Interagency Fire Center reports that the total bur...
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UW-Madison researchers have developed a nonionic cleavable surfactant (NCS) for mass spectrometry (MS)-based proteomics and analysis. Specifically, NCS was designed and synthesized to include a cleava...
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A UW-Madison researcher has developed a celestial guidance system that uses radio imaging of celestial bodies including the galactic plane received by an interferometric antenna array to provide robus...
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UW-Madison researchers have developed a set of novel isobaric chemical tags, DiLeu-Biotin-Azide (DBA), that could be useful in proteomics, particularly quantification of post translational modificatio...
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Soil produces or consumes gases such as carbon dioxide, methane, nitrous oxide, ammonia, and oxygen through normal biological and geological processes. Current soil gas-flux measurement systems are ex...
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UW-Madison researchers developed a new process for preparing proteins, lipids, and metabolites for MS-based multi-omics. The process is based on an monophasic extraction solvent (e.g., n-butanol) that...
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A UW researcher has developed a digital system for controlling pressure oscillations within a wellbore, as well as associated monitoring equipment and analysis codes. The equipment includes a wellhead...
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Fluorescent microscopes, including wide-field, confocal and super-resolution, are widely used instruments in a variety of research fields but require routine calibration and maintenance. Calibration r...
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Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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Single particle cryo-electron microscopy is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many new biologi...
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Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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Light microscopy is a well-established tool to study protein dynamics and protein functions in fixed and living cells. One limitation of light microscopy is that its diffraction limit (optical resolut...
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UW-Madison researchers have developed a novel mass spectrometry (MS)-based method for simultaneous qualitative and quantitative protein citrullination analysis from biological and clinical samples. Th...
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Coherent light sources, in which the photons have highly matched frequencies and phases, are commonly produced by lasers. In a laser, the atoms of a laser medium are stimulated to excite the electrons...
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UW-Madison and Morgridge Institute researchers have identified developed an improved method for depositing samples on electron microscopy (EM) grids. The technology leverages a modified mass spectrome...
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UW-Madison researchers have developed cell-based DNA sensors to achieve easy, accurate, and cost-effective detection of pathogens. Using synthetic biology, the inventors engineered the naturally compe...
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A UW-Madison researcher has developed an improved method and associated system for coherent multidimensional spectroscopy (CMDS). CMDS is based on the formation of Schrӧdinger cat states by exciting ...
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Building off of their prior discovery (Photo-Cleavable Surfactants P180335US02), UW-Madison researchers disclose an improved method for exosome proteomics. The method leverages the researchers’ phot...
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Soft materials are everywhere. In many applications, valuable information about the strength of these materials enables more precise control in everything from cutting and processing soft foods to des...
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Building off their earlier work with LC-infused multilayer films, the inventors developed a method for directly infusing LCs into porous PTFE membranes.  The resulting materials have desirable charac...
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UW-Madison researchers have developed a well-plate for cell culture that allows the user to finely define the location and temporal profile of multiple gradients including oxygen, nutrients, chemoattr...
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UW-Madison researchers have developed improved methods and systems for characterizing soil using visible-near-infrared spectroscopy (vis-NIRS) data. Combining their spectrographic data with additional...
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