Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or m...
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The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
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Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
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The present disclosure relates provides compounds according to Formula I or Formula II as well as compositions including such compounds useful for the prevention of schistosomiasis infection and/or sw...
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Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
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Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are...
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Drug resistant pathogens continue to emerge as the rate of the development of new antimicrobials to combat them continues to decline. Alarmingly, slow-growing bacteria associated with dangerous and pr...
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Staphylococcus epidermidis is an important Gram-negative bacterial pathogen in hospital-acquired infections, and the most common cause of infections on indwelling medical devices. The costs related to...
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The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
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Podophyllotoxin is a natural product derived from a plant. Although two clinically useful glycosylated analogs have been developed for treating cancer, podophyllotoxin is difficult to synthesize, hind...
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HIV infection, AIDS and AIDS-related complex (ARC) remain serious and ongoing diseases compromising the human immune system. Protease inhibitors, which interfere with the replication cycle of HIV, are...
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Human immunodeficiency virus (HIV) affects over 1.2 million Americans each year, with approximately 50,000 new infections per year. Current treatment includes HIV combination regimens comprising rever...
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Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for eight million human infections and two million deaths worldwide each year. M. tuberculosis infections can be treated...
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Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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‘Staph’ infections, particularly by Staphylococcus aureus strains, can cause skin ailments and more serious conditions like heart valve inflammation and toxic shock syndrome. These strains also ar...
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Influenza virus causes millions of infections each year worldwide. Human parainfluenza virus (PIV) types 1,2,3 and respiratory syncytial virus (RSV) types A and B are the major viral pathogens respons...
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Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
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Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands...
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