A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
Learn More

Building off of their prior discovery (Photo-Cleavable Surfactants P180335US02), UW-Madison researchers disclose an improved method for exosome proteomics. The method leverages the researchers’ phot...
Learn More

UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with age and l...
Learn More

UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously discl...
Learn More

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
Learn More

UW researchers have developed modified genetically encoded plasma membrane voltage probes for monitoring mitochondrial and ER membrane voltage gradients. A fluorescence protein tag was coupled with a ...
Learn More

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
Learn More

UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
Learn More

UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
Learn More

UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
Learn More

Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
Learn More

Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
Learn More

Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
Learn More

Viruses maximize their genetic potential through several mechanisms including expressing multiple protein products from a single mRNA template. A crucial mechanism is conserved by both retroviruses, i...
Learn More

UW-Madison researchers have cloned, sequenced and characterized the genome from an isolate of the RV-C45 genotype, and they’ve provided the cDNA for a high titer HRV-C (C45-2A-D41K), as well as the ...
Learn More

UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta” is a...
Learn More

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
Learn More

The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
Learn More

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs ...
Learn More

Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library ...
Learn More

The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
Learn More

Devices, methods and kits are disclosed for preparing and administering less-painful formulations of Botulinum toxin. The devices, methods and kits of the present invention are comprised of or use an ...
Learn More