Growth factor regulation is a key function of the extracellular matrix and critical for proper blood vessel growth and maturation during wound healing. In particular, blood vessel sprouting is essenti...
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Collagen is the most abundant protein in vertebrates, providing support to virtually every tissue including skin, bone and blood vessel. It is of critical importance in wound healing.Given its signifi...
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Cancer treatment planning remains an ongoing challenge to oncologists and patients alike, with each cancer being genetically unique and requiring personalized approaches. Greater outcome success will ...
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"Orthobiologics" provides an improved method of treating fractures and other bone defects. This therapy employs inductive molecules, such as bone morphogenetic protein-2 or bone morphogeneti...
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Drills are commonly used during orthopedic surgery to place screws that allow fixation of fractured bones. One problem that surgeons face while drilling is the overlying soft tissue becoming entangled...
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Wound healing is a complex and dynamic process of rebuilding skin and tissue. Chronic or impaired wounds result when tissues fail to progress through the necessary stages of healing. This is a signifi...
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Chitosan is a soluble biopolymer derived from chitin, which is a structural element in the shell of marine arthropods.  Chitosan is used in water processing and agriculture.  It also is used in band...
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A fracture requiring orthopedic treatment occurs approximately every 14 seconds in the United States.  Musculoskeletal conditions cost an estimated $254 billion each year in the United States, and bo...
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Oral ingestion of pharmaceuticals currently is considered the safest, most convenient and most economical method of drug administration. However, oral delivery of many pharmaceuticals is not possible ...
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Many human diseases and conditions can be treated by implanting devices within the body. However, these devices may be rejected by the body’s immune system or “fouled” by the accumulation of bac...
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Biomaterial scaffolds for tissue engineering perform three primary functions.  They provide temporary support, provide a connected porosity to enhance tissue regeneration and guide the regenerated ti...
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Musculoskeletal conditions cost an estimated $254 billion each year in the United States, and bone and joint diseases account for half of all chronic conditions in adults over the age of 50.  Bone-te...
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More than five million people in the United States are afflicted with chronic skin wounds, resulting in billions of dollars in medical expenses each year. The incidence of chronic wounds is expected t...
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Biodegradable scaffolds with highly interconnected pores are potentially useful in tissue engineering. A rigid, highly porous platform could be used to guide growth in tissues such as bone, cartilage ...
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