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325 Results for 'Research Tools'
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Technology
VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME
UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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Adel Talaat, Bubacarr Touray | P220343US02
Technology
Washed Platelet Extract
UW-Madison researchers have developed a washed platelet extract with increased platelet growth factor concentration and decreased total protein relative to platelet rich plasma, and methods of making ...
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Jacques Galipeau, Sabrina Brounts, Andrea Pennati | P190172US03
Technology
HOST FACTORS THAT ENHANCE VIRAL PRODUCTION VIA VIRALLY DRIVEN FITNESS-BASED CRISPR SCREENING
UW-Madison researchers have developed a new screening approach for identifying host factors that impact influenza viral production after the initial infection, and have used the screen to identify doz...
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Andrew Mehle, Cason King | P230021US02
Technology
GENETICALLY ENCODED SYNTHETIC REACTION-DIFFUSION SYSTEM THAT CAN GENERATE PROGRAMMABLE OSCILLATIONS, PATTERNS, AND SPATIOTEMPORAL SIGNALING CIRCUITS IN MAMMALIAN CELLS
Two UW-Madison researchers have developed a programmable reaction-diffusion system, derived from two small bacterial proteins MinD and MinE, that can be encoded into mammalian cells. In addition, the ...
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Scott Coyle, Rohith Rajasekaran | P220268US02
Technology
MICROFLUIDIC DEVICE AND METHOD FOR GENERATING A SKIN CONSTRUCT
Research into new therapies for skin diseases is challenging for a number of reasons. As is known, skin cells are exposed to both atmospheric air and liquids within the body. However, conventional cel...
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Jose Ayuso, Catherine Reed McBain, Seth Zima, Rithvik Turaga, Vijayasaradhi Setaluri | P230351US01
Technology
An Optimized, More Efficient Method for Characterizing Microorganisms and Viruses Using Metagenomics
Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
MICROSCOPE ENABLED 3D BIOPRINTING SYSTEM
UW-Madison inventors have developed a device that controls a series of actuators mounted onto various inverted microscopes (i.e. Nikon TiE II) to add 3D bioprinting and pick and place capabilities. Th...
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Alexander McGhee, Christian Franck | P230307US01
Technology
MULTIPLEXED DILEU-BIOTIN-AZIDE (DBA) TAG ENABLED ISOBARIC TANDEM ORTHOGONAL PROTEOLYSIS ACTIVITY-BASED PROTEIN PROFILING (ISOBOP-ABPP) PLATFORM FOR HIGH-THROUGHPUT QUANTITATIVE PAN-PTM ANALYSIS
UW-Madison researchers have developed a set of novel isobaric chemical tags, DiLeu-Biotin-Azide (DBA), that could be useful in proteomics, particularly quantification of post translational modificatio...
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Lingjun Li, Miyang Li, Min Ma | P220286US02
Technology
NOVEL CELL LINES SUPPORTIVE OF ROBUST LACTATE DEHYDROGENASE VIRUS (LDV) INFECTION
A UW-Madison researcher has created a cell line capable of growing LDV virus in vitro. The inventor explains that he made an educated guess as to what the receptor for this virus might (CD163) be and ...
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Adam Bailey, Teressa Shaw, Cody Warren | P230385US01
Technology
NOVEL CELL LINES SUPPORTIVE OF ROBUST ARTERIVIRUS INFECTION
A UW-Madison researcher has developed FcRn-overexpressing cell lines that are susceptible to arterivirus infection. Through a genetic screen, the inventor discovered that the neonatal Fc receptor (FcR...
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Adam Bailey, Teressa Shaw, Cody Warren | P230384US01
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
Methods for Bioprinting Functional Human Neural Tissues
Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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Su-Chun Zhang, Yuanwei Yan | P220006US02
Technology
ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS
UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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Andrew Buller, Allwin McDonald | P220120US02
Technology
Characterization Via Homologizing Disparate Speech Terminology
Aspects of the present disclosure from UW Madison researchers are directed to methods and apparatuses involving characterization via homologizing disparate speech terminology. As may be implemented in...
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Joao Ricardo Reboucas Dorea, Rafael Ferreira | P200128WO01
Technology
SITE-SELECTIVE DEUTERATION OF AMINO ACIDS THROUGH DUAL PROTEIN CATALYSIS
UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a small ...
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Andrew Buller, Tyler Doyon | P220181US02
Technology
METHODS OF DESIGNING PRODUCTION OF MICROBIAL COMMUNITIES, METHODS OF PRODUCING MICROBIAL COMMUNITIES, AND MICROBIAL COMMUNITIES PRODUCED THEREBY
UW-Madison researchers disclose an improved method for generating diverse microbiomes. The method leverages growth media composition and species inoculum ratios to control the makeup of the consortia,...
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Ophelia Venturelli, Bryce Connors, Brian Pfleger | P220011WO01
Technology
High-Throughput Tool for Developing Enzyme-Mimicking Catalysts
Catalysts play countless roles in modern society including production of fertilizer, synthesis of plastics and other ubiquitous materials and development of pharmaceuticals. However, many catalysts re...
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Jeffrey Martell, Edward Pimentel, Justice Merrifield | P220207US02
Technology
MONOCLONAL ANTIBODY REAGENTS DIAGNOSTIC FOR CDHR3, THE RHINOVIRUS-C CELLULAR RECEPTOR PROTEIN, DOMAINS EC1, EC2, EC5 AND EC6
UW-Madison researchers have developed and characterized nine murine monoclonal antibody (mAb) reagents that react uniquely with the EC1 (2x), EC2 (2x), EC5 (3x), and EC6 (2x) extracellular cadherin re...
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Ann Palmenberg, Marchel Hill, Kelly Watters, Xander Kessler | P230117US01
Technology
VACO6
A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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James Willson | P230180US01
Technology
PROBIOTIC STRAIN COLLECTION TO STUDY PROPHAGES
UW-Madison researchers have developed a number of variants of lytic strain L. reuteri ∆Φ1attB1∆Φ2∆attB2 (WARF case P170020). They are:
L. reuteri∆Φ1, in which prophage #1 is deleted from th...
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Jan Peter Van Pijkeren, Jeehwan Oh | P230139US01
Technology
PHOTO-CLEAVABLE SURFACTANTS
UW-Madison researchers have developed photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded ...
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Ying Ge, Song Jin, Tania Guardado Alvarez, Kyle Brown | P180335US03
Technology
Methods Of Genome Editing Including Controlled Opening Of Chromatin
UW-Madison researchers developed an improved method of gene editing human iPSCs through CRISPR-Cas. They added the histone deacetylase small molecule inhibitor Trichostatin A (TSA) before addition of ...
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Krishanu Saha, Kaivalya Molugu | P220049US02
Technology
RHESUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE Rh2431
A UW-Madison researcher has developed a Rhesus Macaque induced pluripotent stem cell (iPSC) line, called the Rh2431 iPSC line.
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John Maufort | P230112US01
Technology
UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with age and l...
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Wei Guo, Yanghai Zhang | P230097US01
Technology
CYNOMOLGUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE cy0657
A UW-Madison researcher has developed a Cynomolgus Macaque induced pluripotent stem cell (iPSC) line, called the cy0657 iPSC line.
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John Maufort | P230113US01