UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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UW-Madison researchers have identified new mutations that promote replication of influenza A viruses to high titers in embryonated chicken eggs and would therefore increase the manufacturing yield for...
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UW-Madison researchers have developed a washed platelet extract with increased platelet growth factor concentration and decreased total protein relative to platelet rich plasma, and methods of making ...
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UW-Madison researchers have developed methods for making and using modified influenza gene products, alone or in combination, to inhibit WT virus replication, to serve as immunostimulatory agents, or ...
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UW researchers have created a biological therapeutic that stimulates the immune system to fight solid tumors. The researchers fused the cytokines IL-6 and IL- together to form a bifunctional biomol...
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The present invention from UW Madison researchers is a fusion protein made of the full length PDL-1 transmembrane protein and full length IDO cytosolic protein which the inventors termed PIDO. These t...
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UW-Madison researchers have developed a novel platform that can selectively and sustainably scavenge ROS in inflamed colon tissues while also improving probiotic delivery for gut microbiota homeostasi...
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UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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UW Madison researchers have developed RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-...
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The UW/VA inventor showed that hCG raises circulating sex hormone levels in a mouse model for TBI as compared to sham treated mice. The data indicated that 1) craniectomy is sufficient to induce persi...
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UW-Madison researchers, in collaboration with a professor from the University of Missouri, propose using the cryptic lineages (4-24 amino acid substitutions) of the SARS-CoV-2 spike protein sequence t...
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UW-Madison researchers have developed a SARS-CoV-2 live-attenuated vaccine virus based on the original Wuhan genome but lacking the envelope (E) open reading frame. This vaccine virus replicates effic...
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UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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UW-Madison researchers have discovered that using allogenic arterial endothelial cells (not genetically modified to alter the immune response) perform better than hypoimmunogenic cells for producing s...
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UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
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Clostridium botulinum produces the lethal botulinum neurotoxin (BoNT). There are several types of BoNT, and the subtype BoNT/A1 is used medically to treat muscle movement disorders and cosmetic concer...
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UW Madison researchers have developed a virus-free, CRISPR-Cas mediated method of generating T cells that target senescent cells. These modified T cells could be used to treat Alzheimer’s Disease an...
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The present invention relates to a ‘sugar fermentate of edible fungi’ (i.e., cultures of GRAS species from the genus Aspergillus) that exhibits antimicrobial activity (e.g., against Listeria monoc...
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UW-Madison researchers have developed a series of mutant influenza B viruses that incorporate mutations in the HA1 protein that cause the virus to react with sera generated via exposure to the opposit...
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UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
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UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tumor activi...
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