Wisconsin Alumni Research Foundation

Technology

Artificial Transcription Factors and Uses Thereof

Transcription factor expression can profoundly alter the transcriptional dynamics of a cell, even inducing the transition to a new cell fate. Four transcription factors – Oct4, Sox2, Klf4, and c-Myc...
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Aseem Ansari, Asuka Eguchi | P160383US02

Technology

Derivation of Human Microglia from Pluripotent Stem Cells

Microglia act as the first and main form of active immune defense in the central nervous system. They are the primary source of brain cytokines and have been implicated in chronic neuroinflammation (e...
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James Thomson, Nicholas Propson, Michael Schwartz, Zhonggang Hou, Gene Uenishi, Igor Slukvin, William Murphy, Jue Zhang | P140410US02

Technology

Xenogen-Free Culture Medium for Stem Cells

With the advent of human pluripotent stem cell technologies, endothelial and blood lineage (hematopoietic) cells can be produced in vitro for functional studies and therapies. Efficient differentiatio...
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Igor Slukvin, Gene Uenishi | P130178US02

Technology

Method of Forming Dendritic Cells from Embryonic Stem Cells

Dendritic cells are used as a base for vaccines and in the study of antigen processing within the human body. However, obtaining large quantities of the cells, which are generated in bone marrow, is l...
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Igor Slukvin, James Thomson, Maksym Vodyanyk, Maryna Gumenyuk | P04434US

WARF