Wisconsin Alumni Research Foundation

Technology

Treating Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a disorder driven by overproliferating leukemia cells in bone marrow and blood. Targeted therapy uses thyrosine kinase inhibitors to inhibit leukemia cells, but fails...
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Igor Slukvin, Kran Suknuntha | P130277US02

Technology

Thermogel for Combination Drug Delivery

As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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Glen Kwon, Hyunah Cho | P130338US03

Technology

Improving Drug Delivery with Boronic Acids

The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Gregory Ellis, Michael Palte | P110315US02

Technology

Method of Forming Dendritic Cells from Embryonic Stem Cells

Dendritic cells are used as a base for vaccines and in the study of antigen processing within the human body. However, obtaining large quantities of the cells, which are generated in bone marrow, is l...
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Igor Slukvin, James Thomson, Maksym Vodyanyk, Maryna Gumenyuk | P04434US

Technology

Multilayer Tissue Regeneration System

Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

Technology

Blood-Brain Barrier Targeting Antibodies

Even though therapeutic compounds have been developed for neurologic disorders, such as Alzheimer’s disease, these conditions remain difficult to treat, largely because of the blood-brain barrier. T...
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Eric Shusta, Xin Wang, Yongku Cho | P06056US

WARF