Microorganisms, such as fungi, produce a variety of secondary metabolites.  These secondary metabolites display a broad range of activities, including antibiotic, immunosuppressant, phytotoxic and my...
Learn More

A cell membrane is made up of lipid bilayers that include ion channels for controlling the flow of ions into and out of the cell. Certain ion channels open in response to signaling molecules, includin...
Learn More

There is a lack of effective and non-destructive treatments for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits ang...
Learn More

The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
Learn More

Effective and non-destructive treatments are needed for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits angiogenesi...
Learn More

In patients who develop breast cancer, malignant tumors frequently begin in somatic mammary stem cells. In addition, breast tumors have a stem cell component that propagates the tumor, which may expla...
Learn More

Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful therapeutics for diseases such as obesity and diabetes.
Learn More

Johne’s disease is a contagious, chronic and usually fatal wasting disease that primarily affects the small intestine of ruminants. It is a worldwide problem with no known treatment and infects 25 t...
Learn More

Microorganisms produce a variety of biologically active secondary metabolites, which display a range of useful antibiotic and immunosuppressant activities. One class of secondary metabolites, known as...
Learn More