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324 Results for 'Research Tools'
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Technology
Bovine Macrophage Cell Line
Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
New Viral Propagation Method Yields Insight Into Childhood Asthma
In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
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James Gern, Yury Bochkov, Ann Palmenberg | P140382US02
Technology
Adapted Rhinovirus C for Maximum Virus Yield
Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02
Technology
Rat Model of Schizophrenia for Research and Preclinical Study
Schizophrenia is a complex neuropsychiatric disease afflicting up to 1 percent of the worldwide population. It affects perception, behavior and thinking and can have devastating social ramifications. ...
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John-Paul Yu, Clifford Rubinstein | P160418US01
Technology
Monomeric Fluorescent Protein-Ligand Complexes with Strong Fluorescence in the Far-Red Region
Fluorescent proteins can be found today in most molecular biology laboratories. Since the discovery of Green Fluorescent Protein (GFP) in the early 1960s, fluorescent molecules have revolutionized man...
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Wayne Schaefer, Ramaswamy Subramanian, Swagatha Ghosh | T150029WO01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Bio-Based Production of Non-Straight-Chain and Oxygenated Fatty Acids for Fuels and More
Fatty acids generally can be classified as straight-chain or non-straight-chain. Non-straight-chain fatty acids are less abundant and highly valued in dietary supplements, cosmetics, pharmaceuticals, ...
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Timothy Donohue, Rachelle Lemke, Joshua Coon, Amelia Peterson, Michael Westphall | P140318US02
Technology
Modified E. coli for Enhanced Production of Pyruvate, Ethanol
Pyruvate is a starting material for synthesizing a variety of biofuels and chemicals. It can be readily converted into more than 60 commercial chemicals, including ethanol and several active pharmaceu...
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Jennifer Reed, Xiaolin Zhang | P140301US02
Technology
High-Throughput Genome Editing and Engineering of Industrial Yeast, Other Fungi
As the industrial uses of yeast and other fungi expand, new systems are needed to genetically optimize strains for their intended use. In particular, the ability to manipulate prototrophic and diploid...
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Christopher Hittinger, William Alexander | P140240US03
Technology
Poly(UG) Polymerase: A Useful New RNA Tool
Enzymes called ribonucleotidyl transferases (NTases) add nucleotides to the ends of RNAs. At present only a few such enzymes are known, such as poly(A) polymerases and poly(U) polymerases. The selecti...
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Marvin Wickens, Melanie Preston | P140268US02
Technology
Circulating Tumor Cell Assay Using Simple Blood Draw
Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01
Technology
Accurate Determination of Metabolite Concentrations in Cell Extracts or Biological Fluids
Metabolomics, or the systematic study of all metabolites in an organism, is one of the fastest growing areas of scientific research. Nuclear magnetic resonance (NMR) spectroscopy is one tool used to a...
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John Markley, Ian Lewis, William Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli | P07362US
Technology
Nanopore Antennas for Ultrahigh Speed DNA Sequencing
‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01
Technology
New Mass Spectrometry Detector Uses Optically Active Membrane
Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01
Technology
Multiplexed Mass Spectrometry Quantification with Neutron-Encoded Mass Tags
In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Joshua Coon, Alexander Hebert | P130032US01
Technology
Reprogrammed Stem Cell Line for Research: IISH4i-CBT4
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
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Igor Slukvin, Kejin Hu, James Thomson | P120130US02
Technology
Reprogrammed Stem Cell Line for Research: IISH3i-CB6
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying blood development in vitro.
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Igor Slukvin, Kejin Hu, James Thomson | P120130US01
Technology
Synthesis of High-Density Oligomer Microarrays
To save time and costs, many alternatives to conventional DNA sequencing have been proposed. One approach utilizes an array of oligonucleotide probes (short nucleic acid chains) synthesized by photoli...
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Franco Cerrina, Viktoriya Golovkina | P05183US
Technology
New Disulfide-Bond Reducing Agent
Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P140284US01
Technology
Predicting Protein Hot Spot Residues
Most biological processes involve multiple proteins interacting with each other. While the principles governing protein-protein interactions are not fully understood, it is known that a small subset o...
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Julie Mitchell, Xiaolei Zhu, Steven Darnell | P140357US01
Technology
New Protein Production Strategy for Plants
In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Aurelie Rakotondrafara, Jincan Zhang | P140069US02
Technology
Improved Ref Nuclease for Site-Specific DNA Cleavage
Restriction enzymes are commonly used to cleave double-stranded DNA. These enzymes bind to specific sequences of DNA (the ‘restriction site’) and cleave the DNA either at the recognition site or a...
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Michael Cox, Angela Gruber, Tayla Olsen | P130114US02
Technology
Controlling the Formation of Stem Cell Colonies with Tailored SAM Array
The substrate on which cells are cultured is key to successful growth and tissue generation. For example, it has been shown that attachment to a substrate by human embryonic stem cells influences whet...
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William Murphy, Angela Xie | P150062US01
Technology
Hydrogel Arrays for Screening Cell-Substrate Interactions, Now in Multiwell Format
While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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William Murphy, Ngoc Nhi T. Le | P140305US01