Maturing protein analysis technologies continue to elucidate life’s chemical architecture with a precision even recently unimaginable. Mass spectrometry (MS), which ionizes and fragments proteins fo...
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Surface plasmon resonance (SPR) imaging has demonstrated its ability to monitor interactions between biological moieties in real time without the aid of chemical labels such as fluorophores and radioi...
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Despite the growing interest in the natural interactions between different cellular compartments— and the increasing need to model these phenomena in vitro—no method currently in practice in biolo...
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Detection of magnetic fluctuations is vital to endeavors from space navigation to oil exploration. UW–Madison researchers previously developed a method that utilizes sensitive alkali atoms—polariz...
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As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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A magnetometer is a scientific instrument used to measure the strength and/or direction of magnetic fields. It has applications in areas such as navigation systems, geophysics and drilling/mining expl...
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Responsive hydrogels can respond to external stimuli such as temperature, pH, photons and antigens, which makes them applicable as functional materials in drug/gene delivery devices, microlenses and s...
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The minimum inhibitory concentration (MIC) of a compound is the lowest dose that prevents the growth of a cell during a set time interval. Because of the increase in antibiotic-resistant bacteria and ...
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One type of light-emitting semiconductor laser is the Quantum Cascade Laser (QCL). Extending QCLs to short emission wavelengths (i.e., less than 4.0μm) is challenging due to strain-relaxation conside...
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Two-dimensional spectroscopy can reveal interactions between coupled systems of atoms and/or molecules. Advanced spectroscopy techniques including two-dimensional infrared (2-D IR) and electronic (2-D...
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Intersubband semiconductor lasers represent a new type of laser that emits photons when electrons within a quantum-well structure release their energy during transit from high- to low-energy states. A...
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Quantitative analysis in chemistry is the determination of the absolute or relative abundance of substances present in a sample. For biological samples, quantitative analysis performed via mass spectr...
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Conventional 1300 nm lasers are based on the InGaAsP or InGaAlAs quantum well active material system on an InP substrate. However, these 1300 nm lasers experience poor lasing performance when operated...
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Effective isolation of nucleic acids from biological samples is an essential prerequisite for efficient downstream amplification, detection and quantification of specific genetic sequences via quantit...
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Molecule-molecule interactions, including interactions between proteins, nucleic acids and other small molecules, are important in a variety of cellular events. A number of physical, molecular biologi...
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Quantifying cell adhesion strength is crucial for the development of implantable biomaterials and tissue scaffolds, as well as in understanding many fundamental physiological and disease processes. Ho...
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UW–Madison researchers previously developed high-power quantum cascade lasers (QCLs) with active-photonic-crystal structures to provide improved high-power, narrow-beam laser sources that operate in...
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Liquid crystal materials are promising candidates for many sensing and interfacial applications. Liquid crystals respond to and amplify small changes in temperature, electric or magnetic fields, shear...
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Mass spectrometry (MS) has become the principal tool for routine identification of proteins and their post-translational modifications (PTMs). Quantification of the amounts of proteins and PTMs is req...
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Electromagnetic radiation may be generated by the acceleration or deceleration of charged particles such as electrons. Synchrotron radiation occurs when the trajectory of high-speed electrons is curve...
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Placing sensors that can monitor properties such as temperature and strain directly into a manufacturing environment can allow effective monitoring and control of manufacturing processes. By continuou...
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Now that complete sequence information is available for many organisms, researchers are focusing on the analysis of single genomic DNA molecules. A key issue in this analysis is how to unravel and mar...
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Mass spectroscopy is an analytical technique used to identify, quantify and characterize unknown compounds based on the elemental masses that make up the compounds.  The unknown particles are ionized...
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Microfluidic systems and methods can provide many functions of larger systems and facilities, such as entire laboratories, with increased efficiency as well as reduced size, cost and complexity. Such ...
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Mass spectrometers are analytic instruments that precisely measure the mass of molecules, and therefore may be used to determine composition and molecule identity based on mass data. Generally, the mo...
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