UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
Learn More

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
Learn More

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
Learn More

UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
Learn More

A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamm...
Learn More

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
Learn More

Schizophrenia is a complex neuropsychiatric disease afflicting up to 1 percent of the worldwide population. It affects perception, behavior and thinking and can have devastating social ramifications. ...
Learn More

Every year about two million cases of traumatic brain injury (TBI) occur in the United States, caused by falls, car crashes, sports collisions and other injuries. TBI can lead to a host of health prob...
Learn More

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
Learn More

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
Learn More

Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
Learn More

Glaucoma, the second leading cause of blindness in the United States, is an eye disease that results in optic nerve damage and loss of vision. However, few large-eyed models of spontaneous glaucoma ex...
Learn More

Tumor xenograft mouse models have been created by injecting human cancer cell lines into immune deficient mice. However, when the effects of various interventions on these models are assessed, the res...
Learn More

Many of those currently on waiting lists for liver transplants are victims of liver failure associated with hepatocyte toxicity. This toxicity can be caused by alcohol abuse, or by prescription or non...
Learn More

Cytochrome P450 (CYP) is a family of predominantly hepatic enzymes known to be important in the metabolism of many drugs, carcinogens and other chemicals of pharmacologic and toxicologic significance....
Learn More

Calcium-activated potassium channels are a type of ion channel that is important in many physiological processes.
Learn More

Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabet...
Learn More

When using live vertebrate animals, principal investigators for any activity supported by a Public Health Service (PHS) agency, such as the FDA, NIH or CDC, must comply with the PHS policy on Humane C...
Learn More

Accurate monitoring of gene expression is critical to determining those patterns of expression correlating with exposure to certain drugs or toxins. By elucidating these patterns, researchers may be a...
Learn More

Antioxidant response elements (AREs) are small segments of DNA that turn on a wide variety of genes in response to oxidative stress. They are of particular interest in the study of cancer treatment an...
Learn More

The gene mdm2 is a negative regulator of p53, which plays a key role in apoptosis and is important in chemotherapy. Mice with knockout mutations in mdm2 would be useful in studying this gene; however,...
Learn More