UW-Madison researchers have discovered rearrangement sequences that can be used to engineer rAAV vectors so that they may assemble larger therapeutic transgenes. Using forward and reverse primers that...
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A UW-Madison researcher has discovered two cell surface biomarkers that can be used to distinguish older and newer MSCs in patient samples, which facilitates the separation of newer MSCs for therapeut...
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UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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UW-Madison researchers have developed a novel lipid nanoparticle for delivering biomolecules. The researchers designed the lipopeptide-based nanoparticle for efficient delivery of various biomolecules...
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Fibroblast Activation Protein (FAP) is expressed in 90% of all solid tumors, making it an attractive target in cancer. Current small molecules targeting FAP clear from the system too rapidly, and FAP-...
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UW-Madison researchers have developed approaches to improve recombinant AAV gene therapy vectors (rAAV) therapies by improving their expression in target cells. The inventors have discovered that the ...
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UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tumor activi...
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UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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UW-Madison researchers have developed a novel fusion protein for inducing Breg cell formation and a method for transforming any human B cell into an IL10-competent, functional Breg cell ex vivo at sca...
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The inventors have developed a novel system for co-differentiation of hepatocytes and hematopoietic progenitors from human embryonic stem cells (ES cells) that mimics a late fetal liver undergoing hem...
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