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8 Results for 'Biomanufacturing'
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Technology
METHOD FOR IMPROVING TRANSCYTOSIS PROPERTIES OF A HUMAN BLOOD-BRAIN BARRIER MODEL
UW-Madison researchers have developed a blood-brain barrier (BBB) model with in vivo-like BBB transcytosis properties using a new method that improves the fidelity of highly selective, cross-barrier ...
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Eric Shusta, Sarah Boutom, Yunfeng Ding, Benjamin Gastfriend, Sean Palecek | P230318US02
Technology
Microorganisms And Methods For Producing Reuterin
UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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Jan Peter Van Pijkeren, Zhiying Wang | P230254US02
Technology
REAGENTS AND METHODS FOR PREPARING ROBUST MESENCHYMAL STROMAL CELLS FOR THERAPY
A UW-Madison researcher has discovered two cell surface biomarkers that can be used to distinguish older and newer MSCs in patient samples, which facilitates the separation of newer MSCs for therapeut...
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Wan-Ju Li | P220259US02
Technology
HOST FACTORS THAT ENHANCE VIRAL PRODUCTION VIA VIRALLY DRIVEN FITNESS-BASED CRISPR SCREENING
UW-Madison researchers have developed a new screening approach for identifying host factors that impact influenza viral production after the initial infection, and have used the screen to identify doz...
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Andrew Mehle, Cason King | P230021US02
Technology
Methods for Bioprinting Functional Human Neural Tissues
Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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Su-Chun Zhang, Yuanwei Yan | P220006US02
Technology
ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS
UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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Andrew Buller, Allwin McDonald | P220120US02
Technology
SITE-SELECTIVE DEUTERATION OF AMINO ACIDS THROUGH DUAL PROTEIN CATALYSIS
UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a small ...
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Andrew Buller, Tyler Doyon | P220181US02
Technology
METHODS OF DESIGNING PRODUCTION OF MICROBIAL COMMUNITIES, METHODS OF PRODUCING MICROBIAL COMMUNITIES, AND MICROBIAL COMMUNITIES PRODUCED THEREBY
UW-Madison researchers disclose an improved method for generating diverse microbiomes. The method leverages growth media composition and species inoculum ratios to control the makeup of the consortia,...
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Ophelia Venturelli, Bryce Connors, Brian Pfleger | P220011WO01