UW-Madison researchers have developed a novel, cross-species antibody to fibroblast activation protein (FAP). The researchers identified the antibody through screening of a phage display library. That...
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Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
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Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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UW-Madison researchers have identified and validated a set of human T cell specific biomarkers that can predicti graft-vs-host disease (GVHD) and/or relapse following allogeneic hematopoietic stem cel...
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Using two sets of comparative patient samples (hospitalized COVID-19 patients vs controls from 3 years ago, and hospitalized COVID-19 patients vs patients hospitalized for other conditions), the inven...
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Prostate cancer is the most commonly diagnosed disease in men. Current clinical practice for prostate cancer screening uses the prostate specific antigen (PSA) test. However, PSA-based screening detec...
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A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at l...
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A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the...
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Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Colorectal cancer is a major cause of cancer-related morbidity and mortality in developed nations, causing more than 600,000 deaths worldwide every year. While early detection of localized colorectal ...
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Advances in screening and detection have led to an increase in the diagnosis of early stage breast cancer. Plotting the optimal course of treatment (i.e., more or less aggressive) remains a challenge,...
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Prostate cancer is the second most common cancer in American men, causing more than 27,000 deaths every year. An estimated one man in seven will be diagnosed with prostate cancer during his lifetime.E...
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Ovarian cancer is the most fatal gynecological cancer, killing 15,000 women in the Unites States every year. The overall five-year relative survival rate for women with ovarian cancer is 46 percent. T...
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Almost 200,000 men in the United States develop prostate cancer each year. More than 60,000 people develop melanoma. Early diagnosis is key to survival because the best treatment and prognosis for the...
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DNA damage occurs in organisms as a result of exposure to environmental chemicals and radiation. Failure to repair this damage can lead to tumor formation and cancer. Although a gene has been found in...
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Each year, approximately 20,000 American women are diagnosed with ovarian cancer and about 15,000 women die of the disease.  The overall five-year relative survival rate for women with ovarian cancer...
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