Wisconsin Alumni Research Foundation

Technology

CARDIAC FIBROBLAST DERIVED EXTRACELLULAR MATRIX

UW-Madison researchers have discovered a novel marker in cardiac fibroblasts and myofibroblasts that reliably predicts extracellular matrix production in cultured cardiac fibroblasts. Sushi Domain Con...
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Eric Schmuck, Amish Raval, Sushmita Roy, Tianhua Zhou | P210363US02

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

Metabolic-based Methods For Modulating Gene Expression

This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US

Technology

Perivascular Drug Delivery System

The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly...
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Lianwang Guo, K. Craig Kent, Shaoqin Gong, Xudong Shi, Guojun Chen | P160359US02

Technology

Bisphosphonates Inhibit Aneurysm Formation and Growth

Aortic aneurysms are weakened or bulging areas in the aorta, the largest blood vessel in the body.  As many as 30,000 deaths may result from ruptured abdominal aortic aneurysms each year, but no drug...
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Dai Yamanouchi, K. Craig Kent, Bo Liu | P100193US02

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