UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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UW-Madison researchers have discovered that using allogenic arterial endothelial cells (not genetically modified to alter the immune response) perform better than hypoimmunogenic cells for producing s...
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UW-Madison researchers have discovered a novel marker in cardiac fibroblasts and myofibroblasts that reliably predicts extracellular matrix production in cultured cardiac fibroblasts. Sushi Domain Con...
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The present technology from UW Madison innovators provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose co...
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HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly...
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Methods of using a small molecule MYH11 agonist to inhibit intimal hyperplasia and to maintain a contractile phenotype in vitro and in vivo are described. Also described herein are methods for generat...
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The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.
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Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
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Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
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Aortic aneurysms are weakened or bulging areas in the aorta, the largest blood vessel in the body.  As many as 30,000 deaths may result from ruptured abdominal aortic aneurysms each year, but no drug...
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