UW-Madison researchers have developed an immortalized keratinocyte cell line from the little brown bat (a species that is now endangered). They utilized that cell line to create a model of bat hiberna...
Learn More

A UW-Madison researcher has developed a novel cell line for studying the dynamics of the protein Ist1. They added a HaloTag onto the 3’ end of IST1 in a human RPE1 cell line. This cell lines provide...
Learn More

UW-Madison researchers have developed a petri dish with locking mechanisms for single-handed operations. As cell culture workflows can be sensitive to contamination, single-handed operation allows use...
Learn More

UW-Madison researchers have developed a new screening approach for identifying host factors that impact influenza viral production after the initial infection, and have used the screen to identify doz...
Learn More

A UW-Madison researcher has created a cell line capable of growing LDV virus in vitro. The inventor explains that he made an educated guess as to what the receptor for this virus might (CD163) be and ...
Learn More

A UW-Madison researcher has developed FcRn-overexpressing cell lines that are susceptible to arterivirus infection. Through a genetic screen, the inventor discovered that the neonatal Fc receptor (FcR...
Learn More

A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
Learn More

UW-Madison researchers have developed a number of variants of lytic strain L. reuteri ∆Φ1attB1∆Φ2∆attB2 (WARF case P170020). They are: L. reuteri∆Φ1, in which prophage #1 is deleted from th...
Learn More

A UW-Madison researcher has developed a Rhesus Macaque induced pluripotent stem cell (iPSC) line, called the Rh2431 iPSC line. 
Learn More

A UW-Madison researcher has developed a Cynomolgus Macaque induced pluripotent stem cell (iPSC) line, called the cy0657 iPSC line.
Learn More

UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously discl...
Learn More

Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of th...
Learn More

The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, with pro...
Learn More

UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
Learn More

UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta” is a...
Learn More

Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
Learn More

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
Learn More

GATA-binding-factor 2 (GATA2) is a transcription factor involved in stem cell maintenance and hematopoietic development. The gene encoding GATA2 often suffers germline and somatic mutations, which res...
Learn More

Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
Learn More

Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
Learn More

Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
Learn More

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untransla...
Learn More

The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
Learn More

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs ...
Learn More

Systems and methods for determining genetic variations of an organism for performing a physiological function. The systems include a number of modules that can be integrated into existing metabolic en...
Learn More