UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
Learn More

The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
Learn More

UW-Madison researchers have discovered methods for alleviating the adverse effects of SSRIs in pregnancy through the co-administration of the known drug ketanserin. Using several in vivo experimental ...
Learn More

The UW/VA inventor showed that hCG raises circulating sex hormone levels in a mouse model for TBI as compared to sham treated mice. The data indicated that 1) craniectomy is sufficient to induce persi...
Learn More

Clostridium botulinum produces the lethal botulinum neurotoxin (BoNT). There are several types of BoNT, and the subtype BoNT/A1 is used medically to treat muscle movement disorders and cosmetic concer...
Learn More

The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished ...
Learn More

This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
Learn More

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.
Learn More

The present invention provides methods for treating sinus-evoked headaches using botulinum toxin injected or applied in multiple subcutaneous locations over divisions of the trigeminal nerve in soft t...
Learn More

This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the potenti...
Learn More

A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a pre-determined dose of UV-containing light from a ...
Learn More

An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed....
Learn More

This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic ...
Learn More

Described herein are CRISPR/Cas9 constructs designed for the C-terminal truncation of human amyloid precursor protein (APP) as well as methods of making and using such a construct.
Learn More

Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder without treatments to halt or reverse disease progression, affecting roughly 9,000 Americans. FRDA is caused by triplet expansion in the fi...
Learn More

Currently, delivering drugs directly into the brain requires invasive surgery. This is because a tight cellular layer called the blood-brain barrier (BBB) not only prevents harmful substances from ent...
Learn More

Friedreich’s ataxia (also referred to as FA or FRDA) is a rare but fatal autosomal recessive neurodegenerative disease. With an estimated incidence of 1 in every 40,000 people, it causes progressive...
Learn More

Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability, affecting 1 in 4,000 males and 1 in 6,000 females. It is characterized by severe learning problems, developmental...
Learn More

Sleep apnea affects an estimated 18 million American adults annually. People with sleep apnea can develop conditions such as systemic and pulmonary hypertension, metabolic syndrome, insomnia, neuro-in...
Learn More

Amyloid-beta (Aβ) peptides play a crucial role in Alzheimer’s disease – they are a main component of the toxic amyloid plaques found in patients’ brains. Aβ is so dangerous because it can aggr...
Learn More

Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
Learn More

According to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. An...
Learn More

Neuropathic pain encompasses a wide range of painful conditions of diverse origins, including diabetic neuropathy, post herpatic neuralgia, post-surgical nerve injuries and many others. Currently ther...
Learn More