The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred...
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The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
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In vivo phage display is a protein library development and screening tool that has proven to be a powerful means of identifying new peptide ligands for specific targeting of organs by drugs and gene t...
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Fungi produce a variety of chemical compounds called secondary metabolites. These compounds display a broad range of activities, including fighting off other fungi and bacteria. They also are useful f...
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Phosphines have many commercial and industrial uses as attachments to rare earth metal catalysts, including specialized uses in asymmetric hydrogenation and other catalytic transformations. Asymmetric...
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Many of the compounds used in drug discovery by pharmaceutical companies consist of a central core structure (aglycon) and various sugar (glycosyl) attachments. Because the sugar moieties of many of t...
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Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated, bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and...
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Microorganisms produce a variety of biologically active secondary metabolites, which display a range of useful antibiotic and immunosuppressant activities. One class of secondary metabolites, known as...
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As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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