Wisconsin Alumni Research Foundation

Technology

STEM CELL FATE ENGINEERING METHODS

UW-Madison researchers have developed a simple and versatile method to spatially pattern hPSC differentiations via localized adsorption of morphogens on substrates. Morphogens including BMP4, noggin, ...
Learn More
Sean Palecek, Gyuhyung Jin | P210249US02

Technology

Simplified Basic Media For Human Pluripotent Cells

Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
Learn More
James Thomson, Guokai Chen | P120133US01

Technology

Fgf Having Enhanced Stability

Methods are provided that exploit thermostable FGF-1 proteins for support of human pluripotent stem cell cultures. Also provided are compositions containing thermostable FGF-1 for culturing of human p...
Learn More
James Thomson, Guokai Chen | P110094US02

Technology

Fgf-2 Having Enhanced Stability

Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins.
Learn More
James Thomson, Guokai Chen, Zhonggang Hou | P110177US02

Technology

Patch for Delivering Therapeutic Cells into Heart

Throughout a person’s lifetime the heart undergoes slow cellular turnover. This steady regeneration is critical to maintaining healthy cardiac function from birth to old age. The heart’s ability t...
Learn More
Eric Schmuck, Kurt Saupe | P110346US02

Technology

Polymer Coating for Cell Culture Substrates

A stem cell’s microenvironment plays a key role in regulating its behavior (e.g., adhesion, migration, proliferation and differentiation). A variety of templates have been used to study stem cell be...
Learn More
Padma Gopalan, William Murphy, Samantha Brittelle | P150079US01

Technology

Clonal Culture of Human Pluripotent Stem Cells

For researchers, cloning human embryonic stem (ES) cells is challenging because it requires growing new colonies from a single cell. One difficulty is very low cloning efficiency – less than 0.1 pe...
Learn More
James Thomson, Veit Bergendahl | P08168US

Technology

Microwells for Controlling Embryoid Body Formation

Embryonic stem cells form aggregates, called embryoid bodies (EBs), before differentiating into distinct types of cells. Clumps of stem cells can vary widely in size, shape and volume, resulting in no...
Learn More
Sean Palecek, Jeffrey Mohr, Juan DePablo | P06196US

WARF