The element fluorine has acquired an ever-increasing prevalence in synthetic drugs and agrochemicals due to its positive impact on the metabolism, chemical stability, and modulating lipophilicity of a...
Learn More

UW-Madison researchers have developed a method of diagnosing cancer through detection of specific fragmentation patterns of cell free DNA in plasma. Their approach is distinctly focused on positioning...
Learn More

UW-Madison researchers have developed a method of stabilizing short antigenic peptides that act as vaccines against infectious disease or cancer. Peptides that bind major histocompatibility complex I ...
Learn More

UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
Learn More

UW-Madison researchers have developed a synthetic peptide through a single amino acid substitution and chemical conjugation of an aromatic molecule at the site of mutation that turns a peptide that bi...
Learn More

UW-Madison researchers have a Clostridium botulinum strain 62A that is a sporulating C. botulinum strain producing high levels of BoNT/A1. A bacterial stock was prepared from a single colony and seque...
Learn More

UW-Madison researchers have developed a high throughput peptide mapping platform by combining a plate-based sample preparation method with direct injection MS analysis. Protein samples are cleaned, re...
Learn More

UW-Madison researchers have developed photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improv...
Learn More

UW-Madison researchers have developed a method of identifying and characterizing DNA fragmentation patterns in circulating tumor cells using targeted circulating tumor cell DNA (ctDNA) panels. These r...
Learn More

UW-Madison researchers developed a novel class of molecules that bind cereblon (CRBN), a ubiquitin ligase. These molecules may be used in the development of PROTAC therapeutics. The researchers starte...
Learn More

Cell therapy is a novel and promising approach to treating diseases such as rheumatoid arthritis, atherosclerosis, acute ischemia, myocardial infarction, diabetes, graft versus host disease and cancer...
Learn More

UW-Madison researchers have developed a novel method for predicting optimal treatment responses in oncology patients based on DNA and RNA sequences in circulating tumor cells. They termed this new met...
Learn More

Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
Learn More

Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
Learn More

A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
Learn More

UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
Learn More

UW Madison researchers have developed a novel way to manufacture large amount of micellular paclitaxel. Rather than using organic solvents to get the paclitaxel solubilized and loaded into micelles, t...
Learn More

UW-Madison researchers have developed a highly efficient biocatalytic route for production of diverse γ-hydroxy amino acids starting from L-aspartate and readily available aldehydes. The method lever...
Learn More

UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a small ...
Learn More

UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
Learn More

A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
Learn More

Building off of their prior discovery (Photo-Cleavable Surfactants P180335US02), UW-Madison researchers disclose an improved method for exosome proteomics. The method leverages the researchers’ phot...
Learn More

UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with age and l...
Learn More

UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously discl...
Learn More

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
Learn More