Wisconsin Alumni Research Foundation

Technology

Single-Domain Antibodies And Variants Thereof Against Met

UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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Andrew Baschnagel, Randall Kimple, Reinier Hernandez, Aaron LeBeau | P230175US02

Technology

Cyclic Peptide-Based Lysosome Targeting Degraders

UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01

Technology

UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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Zachary Morris, Justin Jagodinsky | P220308WO01

Technology

Nonviral Generation of Genome-Edited CAR T Cells

Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02

Technology

Metabolic-based Methods For Modulating Gene Expression

This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US

Technology

Alkylphosphocholine Analogs For Multiple Myeloma Imaging And Therapy

The inventors have discovered that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells, as compared to non-tumor cells. The inventors have further demonstra...
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Chorom Pak, Jamey Weichert, Mario Otto, Roberta Marino, Fotios Asimakopoulos, Benjamin Titz, Kevin Kozak | P150207US03

Technology

Peptide-Nanoparticle Conjugates

Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of β-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and meth...
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Seungpyo Hong, Woo-jin Jeong | P200080US02

WARF