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62 Results for 'Oncology'
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Technology
Single-Domain Antibodies And Variants Thereof Against Met
UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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Andrew Baschnagel, Randall Kimple, Reinier Hernandez, Aaron LeBeau | P230175US02
Technology
Antimony Chelates For Targeted Auger Therapy And Imaging Diagnostics
UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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Jonathan Engle, Aeli Olson, Nikki Thiele, Briana Schrage, Md Faizul Islam | P230454US02
Technology
Cyclic Peptide-Based Lysosome Targeting Degraders
UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01
Technology
Method To Make Small-Molecule Murine Double Minute 2 Protein (MDM2)-Degrading Compounds, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
The development of small-molecule compounds that target the murine double minute 2 protein (MDM2) represents a significant advancement in cancer therapy. MDM2 is known to inhibit the tumor suppressor ...
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Weiping Tang, Bo Wang, Suzhen Wu, Ka Yang | P190076US02
Technology
COMPOSITIONS AND METHODS TO ENHANCE IMMUNE CHECKPOINT BLOCKADE THERAPY AGAINST HYPOXIC TUMORS
UW-Madison researchers have developed an improved delivery system that is able to penetrate the extracellular matrix (ECM) and shuttle surface-conjugated protein cages, composed of collagenases and an...
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Quanyin Hu, Zhaoting Li | P230298WO01
Technology
FERRITIN-TARGETING PROTACS AND METHODS OF INDUCING PYROPTOSIS
UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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Quanyin Hu, Yu Chen | P230104WO01
Technology
Synthetic IL6-IL1beta Fusion Cytokine For Promoting T Cell Cytotoxic Function, T Cell Proliferation, and Anti-Tumoricidal Activity
UW researchers have created a biological therapeutic that stimulates the immune system to fight solid tumors. The researchers fused the cytokines IL-6 and IL- together to form a bifunctional biomol...
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Jacques Galipeau, Rahul Das | P220203US03
Technology
UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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Zachary Morris, Justin Jagodinsky | P220308WO01
Technology
Compositions and Methods to Enhance Therapeutic Efficacy of Cancer Therapies
UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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Zachary Morris, Justin Jagodinsky | P220308US02
Technology
HYDROGEL COMPOSITIONS COMPRISING GASDERMIN D AND AN ESCRT INHIBITOR AND METHODS OF USE THEREOF
UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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Quanyin Hu, Zhaoting Li | P220290US02
Technology
PSMA-Targeting Ligands with Optimal Properties for Imaging and Therapy
Theranostics, a term derived from a combination of therapeutics and diagnostics, is an emerging field of medicine where specific radionuclide disease-targeting agents are used to diagnose and treat me...
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Reinier Hernandez, Anatoly Pinchuk | P210215US02
Technology
Nanoparticles For Potentiating Effects Of Radiation Therapy On Anti-Cancer Immunotherapy
The present technology from UW Madison inventors provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeox...
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Shaoqin Gong, Zachary Morris, Ying Zhang, Raghava Sriramaneni | P210094WO01
Technology
Effective and Robust Method of T Cell Expansion and Activation
Ex vivo expansion and activation of T cells are prerequisites for any form of genetically engineered T cell immunotherapy. Several expansion and activation methodologies have been developed. However, ...
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Peiman Hematti, Debra Bloom | P150198US02
Technology
Nonviral Generation of Genome-Edited CAR T Cells
Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02
Technology
MODULAR DENDRON MICELLES FOR COMBINATION IMMUNOTHERAPY
UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs). The nanoparticles ...
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Seungpyo Hong, Deric Wheeler | P210003WO01
Technology
Multicell Conjugates For Activating Antigen-Specific T Cell Responses
The present invention from UW Madison researchers provides in vitro derived a multicell conjugate comprising an iNKT cell and a dendritic cell (DC). The invention also provides methods of making the m...
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Jenny Gumperz, Dana Baiu | P200046US02
Technology
LPS Priming of Stromal Cells to Generate LPS-specific Exosome Educated Macrophages
Currently there are no cell therapies approved for use against acute radiation injury (ARS). Severe ARS can cause death and the only cell treatment is allogenic bone marrow transplantation (BMT). Unfo...
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Peiman Hematti, John Kink, Christian Capitini | P170215US02
Technology
Metabolic-based Methods For Modulating Gene Expression
This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US
Technology
Unimolecular Nanoparticles For Efficient Delivery Of Therapeutic Cationic Peptides
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be u...
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Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu | P170128US02
Technology
Alkylphosphocholine Analogs For Multiple Myeloma Imaging And Therapy
The inventors have discovered that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells, as compared to non-tumor cells. The inventors have further demonstra...
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Chorom Pak, Jamey Weichert, Mario Otto, Roberta Marino, Fotios Asimakopoulos, Benjamin Titz, Kevin Kozak | P150207US03
Technology
Syndecan Peptides And Polypeptides As Inhibitors Of Vegfr2 And Vla-4
Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very...
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Alan Rapraeger, Oisun Jung | P150222US02
Technology
Amino Thiol Compounds And Compositions For Use In Conjunction With Cancer Therapy
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are admi...
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William Fahl, Daniel Peebles, Richard Copp | P04014US
Technology
Peptide-Nanoparticle Conjugates
Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of β-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and meth...
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Seungpyo Hong, Woo-jin Jeong | P200080US02
Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Weiping Tang, Ka Yang, Hao Wu, Zhongrui Zhang | P180321US05
Technology
Combination Chemotherapy For The Treatment Of Cancer
The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic rib...
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Ronald Raines, Trish Hoang | P170199US02