UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
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UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with age and l...
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Coronaviruses are a group of RNA viruses that can cause disease. Some, such as the common cold, can cause mild disease, while others, such as COVID-19, can be lethal. An unusual characteristic of coro...
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Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal anti...
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R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
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The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Fluorescent proteins can be found today in most molecular biology laboratories. Since the discovery of Green Fluorescent Protein (GFP) in the early 1960s, fluorescent molecules have revolutionized man...
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Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Most biological processes involve multiple proteins interacting with each other. While the principles governing protein-protein interactions are not fully understood, it is known that a small subset o...
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Restriction enzymes are commonly used to cleave double-stranded DNA. These enzymes bind to specific sequences of DNA (the ‘restriction site’) and cleave the DNA either at the recognition site or a...
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Membrane proteins perform many crucial functions in vivo but are difficult to manipulate and study because they are not soluble in simple aqueous buffers. Solubilizing membrane proteins for physical c...
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Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Integral membrane proteins are crucial cellular components, helping to transfer material and signals through the cytoplasm or between different cell compartments. Analyzing the structures and function...
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Membrane proteins play crucial roles in biology but are difficult to handle and analyze because of their physical properties. The structures of these proteins display extensive nonpolar surfaces, whic...
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The yeast two-hybrid system is a powerful technique used to detect protein-protein interactions. The technique has been used to establish physical interactions between genetically identified proteins,...
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Membrane proteins perform many crucial functions in vivo.  Physical characterization of these proteins, including the determination of three-dimensional crystal structures, could improve fundamental ...
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Three hybrid screens are used to detect RNA-protein interactions.  A problem with three hybrid screens has been high background due to some cDNAs binding and activating transcription in the absence o...
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Biological membranes, such as cell membranes, are intrinsically impermeable to ions and polar molecules. Thus, transport of ions through biological membranes requires special channel or pump proteins ...
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Foldamers are synthetic protein oligomers with discrete and predictable folding properties akin to those of natural proteins. They provide molecular tools to investigate large-molecule interactions su...
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Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
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Over the last eight years, academic researchers have been developing a new set of spectroscopic techniques that are multidimensional versions of visible and infrared spectroscopies, such as two-dimens...
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Human embryonic stem (hES) cells are capable of self-renewal, as long as they remain undifferentiated. Culture conditions, including the medium and substrate the cells are grown in, play an important ...
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