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324 Results for 'Research Tools'
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Technology
Charcoal Identification System
The present invention from UW-Madison and USDA Forest Service Forest Products Lab (FPL) researchers is an automated system for identifying the source of wood in a charcoal product. The inventors emplo...
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Prabu Ravindran, Alex Wiedenhoeft | P200110US02
Technology
Microorganisms And Methods For Producing Reuterin
UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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Jan Peter Van Pijkeren, Zhiying Wang | P230254US02
Technology
Human Cell Line Natively Expressing A HaloTag Fusion To IST1, A Protein Involved In Membrane Trafficking And Endosomal Protein Sorting
A UW-Madison researcher has developed a novel cell line for studying the dynamics of the protein Ist1. They added a HaloTag onto the 3’ end of IST1 in a human RPE1 cell line. This cell lines provide...
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Anjon Audhya, Kevin Swift | P240165US01
Technology
Nanobody Expression Vectors
UW-Madison researchers have developed a set of vectors for expressing nanobodies. The researchers engineered a vector system for transferring nanobodies between bacterial and mammalian expression syst...
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Aaron LeBeau, Eric Lake | P240024US01
Technology
Modeling High-Malignant Wilms Tumors With Reprogrammed WIT49Cells (WIT49-iPSC) For Therapeutic Intervention
UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
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Wei Xu, Gui Ma, Wan-Ju Li | P230404US01
Technology
A Single-Handed Petri Dish to Reduce Contamination Risk and Increase User Flexibility
UW-Madison researchers have developed a petri dish with locking mechanisms for single-handed operations. As cell culture workflows can be sensitive to contamination, single-handed operation allows use...
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Aleksandar Wood, Harpreet Singh | P190121US02
Technology
Identifying Sequence Information from Single Molecule Nucleic Acid Measurements
UW-Madison researchers have developed methods for identifying nucleic acid sequence information using single molecule measurements that provide simple, information-rich workflows with high sensitivity...
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David Schwartz, Subhrangshu Nandi, Michael Newton | P180056US02
Technology
FERRITIN-TARGETING PROTACS AND METHODS OF INDUCING PYROPTOSIS
UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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Quanyin Hu, Yu Chen | P230104WO01
Technology
Method Of Identifying Allosteric Biosensor Proteins With New Specificities
UW-Madison researchers have developed an RNA barcode method to measure transcripts produced under an inducible promoter without the need for deep sequencing. The method involves adding a random RNA ba...
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Srivatsan Raman, Kyle Nishikawa, Nathan Novy | P230343US02
Technology
REAGENTS AND METHODS FOR PREPARING ROBUST MESENCHYMAL STROMAL CELLS FOR THERAPY
A UW-Madison researcher has discovered two cell surface biomarkers that can be used to distinguish older and newer MSCs in patient samples, which facilitates the separation of newer MSCs for therapeut...
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Wan-Ju Li | P220259US02
Technology
HELA-ADAPTED RHINOVIRUSES C (RV-C) AND ADAPTIVE GENOMIC MUTATIONS
UW-Madison researchers have developed HeLa cell-adapted Rhinovirus-C (RV-C) variants that induce a strong cytopathic effect and replicate vigorously in HeLa-E8 cells. The inventors had previously show...
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James Gern, Yury Bochkov | P240269US01
Technology
REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION
UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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James Thomson, Jue Zhang | P230071US02
Technology
VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME
UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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Adel Talaat, Bubacarr Touray | P220343US02
Technology
Washed Platelet Extract
UW-Madison researchers have developed a washed platelet extract with increased platelet growth factor concentration and decreased total protein relative to platelet rich plasma, and methods of making ...
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Jacques Galipeau, Sabrina Brounts, Andrea Pennati | P190172US03
Technology
HOST FACTORS THAT ENHANCE VIRAL PRODUCTION VIA VIRALLY DRIVEN FITNESS-BASED CRISPR SCREENING
UW-Madison researchers have developed a new screening approach for identifying host factors that impact influenza viral production after the initial infection, and have used the screen to identify doz...
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Andrew Mehle, Cason King | P230021US02
Technology
GENETICALLY ENCODED SYNTHETIC REACTION-DIFFUSION SYSTEM THAT CAN GENERATE PROGRAMMABLE OSCILLATIONS, PATTERNS, AND SPATIOTEMPORAL SIGNALING CIRCUITS IN MAMMALIAN CELLS
Two UW-Madison researchers have developed a programmable reaction-diffusion system, derived from two small bacterial proteins MinD and MinE, that can be encoded into mammalian cells. In addition, the ...
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Scott Coyle, Rohith Rajasekaran | P220268US02
Technology
MICROFLUIDIC DEVICE AND METHOD FOR GENERATING A SKIN CONSTRUCT
Research into new therapies for skin diseases is challenging for a number of reasons. As is known, skin cells are exposed to both atmospheric air and liquids within the body. However, conventional cel...
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Jose Ayuso, Catherine Reed McBain, Seth Zima, Rithvik Turaga, Vijayasaradhi Setaluri | P230351US01
Technology
An Optimized, More Efficient Method for Characterizing Microorganisms and Viruses Using Metagenomics
Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
MICROSCOPE ENABLED 3D BIOPRINTING SYSTEM
UW-Madison inventors have developed a device that controls a series of actuators mounted onto various inverted microscopes (i.e. Nikon TiE II) to add 3D bioprinting and pick and place capabilities. Th...
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Alexander McGhee, Christian Franck | P230307US01
Technology
MULTIPLEXED DILEU-BIOTIN-AZIDE (DBA) TAG ENABLED ISOBARIC TANDEM ORTHOGONAL PROTEOLYSIS ACTIVITY-BASED PROTEIN PROFILING (ISOBOP-ABPP) PLATFORM FOR HIGH-THROUGHPUT QUANTITATIVE PAN-PTM ANALYSIS
UW-Madison researchers have developed a set of novel isobaric chemical tags, DiLeu-Biotin-Azide (DBA), that could be useful in proteomics, particularly quantification of post translational modificatio...
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Lingjun Li, Miyang Li, Min Ma | P220286US02
Technology
NOVEL CELL LINES SUPPORTIVE OF ROBUST LACTATE DEHYDROGENASE VIRUS (LDV) INFECTION
A UW-Madison researcher has created a cell line capable of growing LDV virus in vitro. The inventor explains that he made an educated guess as to what the receptor for this virus might (CD163) be and ...
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Adam Bailey, Teressa Shaw, Cody Warren | P230385US01
Technology
NOVEL CELL LINES SUPPORTIVE OF ROBUST ARTERIVIRUS INFECTION
A UW-Madison researcher has developed FcRn-overexpressing cell lines that are susceptible to arterivirus infection. Through a genetic screen, the inventor discovered that the neonatal Fc receptor (FcR...
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Adam Bailey, Teressa Shaw, Cody Warren | P230384US01
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
Methods for Bioprinting Functional Human Neural Tissues
Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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Su-Chun Zhang, Yuanwei Yan | P220006US02
Technology
ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS
UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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Andrew Buller, Allwin McDonald | P220120US02