Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In a...
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Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiatio...
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Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues com...
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There remains a need for models that recapitulate complex human tissues and biological processes, and are suitable for screening potentially hazardous compounds. Animal models are of limited value for...
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New therapies are urgently needed to protect patients exposed to high doses of radiation due to accidental trauma, terrorist attack or for medical purposes. Existing drugs (such as potassium iodide an...
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Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
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Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying blood development in vitro.
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The substrate on which cells are cultured is key to successful growth and tissue generation. For example, it has been shown that attachment to a substrate by human embryonic stem cells influences whet...
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While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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Human embryonic stem cells (hESCs) are a useful tool for unveiling the cellular and molecular mysteries of human development. Directed differentiation of hESCs could revolutionize pharmaceutical scree...
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Transfection is the process of introducing nucleic acids into cells. Two main strategies are viral (utilizing viruses as vectors) and non-viral. Non-viral methods are less efficient but attractive for...
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How and why precursor cells differentiate into tissue-specific cell types involves a complex interplay of signals and remains a rich topic of investigation. Outside of the body, for example, certain s...
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Current methods for isolating and culturing primary (stem/progenitor) cells remain unsatisfactory because most primary cells die when transferred to culture, and the remaining cells usually develop mu...
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Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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