UW-Madison researchers have developed a blood-brain barrier (BBB) model with in vivo-like BBB transcytosis properties using a new method that improves the fidelity of highly selective, cross-barrier ...
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A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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UW-Madison researchers have developed a simple and versatile method to spatially pattern hPSC differentiations via localized adsorption of morphogens on substrates. Morphogens including BMP4, noggin, ...
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UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously discl...
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UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior innovat...
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A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Generating cardiovascular cells from pluripotent stem cells holds profound promise for research and therapy, and the past 10 years have witnessed rapid methodological advances for creating de novo hum...
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Given their developmental importance and therapeutic potential, epicardial cells and epicardium-derived cells are a promising progenitor source to restore functional vasculature, maintain cardiomyocyt...
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Endothelial cells derived from human pluripotent stem cells (hPSCs) hold incredible potential for human health, for example, in the engineering of new blood vessels, heart regeneration and screening f...
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The blood-brain barrier (BBB) is made up of brain microvascular endothelial cells (BMECs), which line brain capillaries and control trafficking between the bloodstream and neural tissue. Although esse...
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The present invention provides methods and kits for differentiating podocytes from pluripotent stem cells and from other cell types.
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A method of creating an isogenic multicellular blood-brain barrier model from iPSCs is disclosed.
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Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for ge...
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A population of brain pericyte-like cells, wherein the cells express pericyte markers but do not express ACTA2 and wherein the cells are generated from hPSCs, is disclosed herein.
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Embryonic stem cells form aggregates, called embryoid bodies (EBs), before differentiating into distinct types of cells. Clumps of stem cells can vary widely in size, shape and volume, resulting in no...
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Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g.,...
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Although it is essential to healthy brain function, the blood-brain barrier (BBB) interferes with drug delivery, preventing more than 98 percent of small molecule pharmaceuticals and nearly 100 percen...
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Methods for culturing the pluripotent stem cells to undergo epithelial-to-mesenchymal transition and for generating high-yield, high-purity cardiomyocyte cultures from pluripotent stem cells are descr...
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