UW-Madison researchers have developed a blood-brain barrier (BBB) model with in vivo-like BBB transcytosis properties using a new method that improves the fidelity of highly selective, cross-barrier ...
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A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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Generating cardiovascular cells from pluripotent stem cells holds profound promise for research and therapy, and the past 10 years have witnessed rapid methodological advances for creating de novo hum...
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Given their developmental importance and therapeutic potential, epicardial cells and epicardium-derived cells are a promising progenitor source to restore functional vasculature, maintain cardiomyocyt...
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Endothelial cells derived from human pluripotent stem cells (hPSCs) hold incredible potential for human health, for example, in the engineering of new blood vessels, heart regeneration and screening f...
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A population of brain pericyte-like cells, wherein the cells express pericyte markers but do not express ACTA2 and wherein the cells are generated from hPSCs, is disclosed herein.
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Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g.,...
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Although it is essential to healthy brain function, the blood-brain barrier (BBB) interferes with drug delivery, preventing more than 98 percent of small molecule pharmaceuticals and nearly 100 percen...
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