Drug Discovery & Development
Human Heart Sodium Channel Beta1 Subunit (SCNB1)
WARF: P03207US
Inventors: Jonathan Makielski, Bin Ye
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a cell line that stably expresses the beta1 subunit of the human heart sodium channel.
Overview
The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is thought to be a cell adhesion molecule and may have multiple effects on other proteins.
The Invention
The beta1 subunit of the human heart sodium channel is now available as a biomaterial through WARF. SCNB1 was first cloned in the early 1990s. UW-Madison researchers have now re-cloned this subunit and created a cell line that stably expresses it.
Applications
- Drug testing and screening
- Determining which molecules interact with SCNB1
Key Benefits
- May be co-expressed with alpha subunits of the sodium channel to more faithfully capture normal sodium channel function for electrophysiological and pharmacological studies.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854