Research Tools
Computer-Based Determination of Haplotype
WARF: P05170US
Inventors: Tom Anantharaman, Bud Mishra, Will Casey
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing software for determining an individual’s chromosomal haplotype with greater accuracy and speed.
Overview
Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertions, deletions and single nucleotide polymorphisms (SNPs). A set of variations that tend to be inherited together are called a haplotype.
Haplotype information is extremely powerful because certain genetic variations may be associated with diseases. Determining an individual’s haplotype has traditionally relied on statistics gathered from his/her relatives. However, this approach limits accuracy and resolution.
Haplotype information is extremely powerful because certain genetic variations may be associated with diseases. Determining an individual’s haplotype has traditionally relied on statistics gathered from his/her relatives. However, this approach limits accuracy and resolution.
The Invention
UW–Madison researchers have developed a computer-based method for determining haplotypes. Their system uses genotype data obtained from a wide range of mapping techniques (e.g., experiments with single molecules, families or populations).
The new system identifies polymorphic markers (SNPs, etc.) at one or more contiguous genetic loci and then considers which haplotypes are most likely to account for the observed data. The procedure is nearly linear in the number of markers examined, and therefore more accurate and efficient.
The new system identifies polymorphic markers (SNPs, etc.) at one or more contiguous genetic loci and then considers which haplotypes are most likely to account for the observed data. The procedure is nearly linear in the number of markers examined, and therefore more accurate and efficient.
Applications
- Determining an individual’s chromosomal haplotype
- Assisting the diagnosis and treatment of disease
Key Benefits
- Faster and more accurate
- Cost effective
- Does not rely on data from known relatives/populations
Additional Information
Related Technologies
For current licensing status, please contact Justin Anderson at [javascript protected email address] or 608-960-9853