Therapeutics & Vaccines
Antibacterial Agents Using Small Molecule Macroarrays
WARF: P06361US
Inventors: Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing novel antibiotic compositions that exhibit potent antibacterial activity against MRSA and potentially other Gram-positive pathogens.
Overview
Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually amenable to antibiotic treatment, a highly virulent strain, methicillin resistant S. aureus (MRSA), is a leading cause of hospital-acquired infections in the United States.
The Invention
UW-Madison researchers have developed novel chemical agents that exhibit potent antibacterial activity against MRSA and potentially other Gram-positive bacterial pathogens. To identify these compounds, the inventors developed a versatile discovery platform that couples array technology with high throughput screening techniques to simply and rapidly synthesize small molecules and screen them for antibacterial activity.
Applications
- Treatment of bacterial infections, including infections with antibiotic-resistant bacteria such as MRSA
Key Benefits
- Provides novel antibiotic compositions
- Platform enables facile synthesis, screening and lead optimization of compounds.
- Compounds can be identified without labor-intensive and time-consuming deconvolution steps.
Additional Information
For More Information About the Inventors
Related Intellectual Property
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847