Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
(20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol And Its Uses
WARF: P07496US

Inventors: Hector DeLuca, Lori Plum, Margaret Clagett-Dame


The Invention
This invention discloses (20S)-1.alpha.-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847

WARF