Research Tools
Polyclonal Antibodies Against Cardiovirus 2A, 2B, 2C, 3C, 3A, 3B and 3AB Proteins
WARF: P07499US
Inventors: Ann Palmenberg, Svetlana Amineva, Aleksey Aminev
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in polyclonal antibodies against several cardiovirus proteins.
Overview
Encephalomyocarditis virus, a cardiovirus, causes encephalitis and myocarditis. It is a widespread problem in swine, causing sudden death and reproductive failure and potentially leading to severe economic losses for pork producers. This virus also infects exotic mammals such as elephants and llamas.
The Invention
UW-Madison researchers have developed polyclonal mouse antibodies against recombinant cardiovirus proteins. The antibodies can be used for specific molecular recognition of the cardiovirus proteins in vitro or in vivo using experimental techniques such as ELISA (enzyme linked immunosorbent assay), Western assays, protein immunoprecipitation (IP) and confocal fluorescence microscopy.
Applications
- Studying cardiovirus proteins
- May lead to new means of detecting, preventing and treating cardiovirus infection, including encephalomyocarditis virus infection
Key Benefits
- All reagents have been tested for efficacy.
- Most of the antibodies react with viral precursor proteins, in addition to the mature proteins against which they were raised.
Additional Information
For More Information About the Inventors
Related Technologies
Publications
- Aminev A.G., Amineva S.P. & Palmenberg A.C. 2003. Encephalomyocarditis Virus (EMCV) Proteins 2A and 3BCD Localize to Nuclei and Inhibit Cellular mRNA Transcription but not rRNA Transcription. Virus Res. 95, 59-73.
- Aminev A.G., Amineva S.P. & Palmenberg A.C. 2003. Encephalomyocarditis Viral Protein 2A Localizes to Nucleoli and Inhibits Cap-Dependent mRNA Translation. Virus Res. 95, 45-57.
Tech Fields
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854