Pluripotent Stem Cells
Generation Of Cardiomyocytes From Human Pluripotent Stem Cells
WARF: P110259US02
Inventors: Sean Palecek, Timothy Kamp, Xiaojun Lian
The Invention
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g., by inhibition of Gsk-3 to obtain a first population of cells. Wnt/β-catenin signaling is then inhibited in the first cell population to induce cardiogenesis under fully defined, growth factor free culture conditions.
Additional Information
For More Information About the Inventors
Tech Fields
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