Research Tools
Reprogrammed Stem Cell Line for Research: IISH4i-CBT4
WARF: P120130US02
Inventors: Igor Slukvin, Kejin Hu, James Thomson
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a transgene-free iPSC line generated by reprogramming cord blood cells.
Overview
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
The Invention
UW–Madison researchers have developed a reprogrammed iPSC line called IISH4i-CBT4. Their method generates iPSCs free of transgene and vector sequences from human bone marrow and cord blood mononuclear cells using non-integrating episomal vectors.
Thiazovivin was added to improve reprogramming efficiency when creating this line.
Thiazovivin was added to improve reprogramming efficiency when creating this line.
Applications
- Reprogrammed iPSCs for research
Key Benefits
- Research-grade stem cells
Additional Information
For More Information About the Inventors
Related Technologies
Publications
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857
- Hu K., Yu J., Suknuntha K., et al. 2011. Efficient Generation of Transgene-Free Induced Pluripotent Stem Cells from Normal and Neoplastic Bone Marrow and Cord Blood Mononuclear Cells. Blood. 117, e109–e119.