Research Tools
Identifying Sequence Information from Single Molecule Nucleic Acid Measurements
WARF: P180056US02
Inventors: David Schwartz, Subhrangshu Nandi, Michael Newton
The Wisconsin Alumni Research Foundation is seeking commercial partners interested in developing methods for identifying sequence information from measurements of single nucleic acid molecules. The method detects signals from marker molecule binding at different positions and processes the detected signals to provide sequence information for the single nucleic acid molecule.
The Invention
UW-Madison researchers have developed methods for identifying nucleic acid sequence information using single molecule measurements that provide simple, information-rich workflows with high sensitivity and resolution and are compatible with inexpensive, disposable microfluidic devices. The binding of marker molecules at different positions of a nucleic acid can be detected with techniques including fluorescence. Combining multiple series of marker molecule binding events can provide complementary sequence information. The PRIMR algorithm then is used to process the data and generate a sequence profile.
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For current licensing status, please contact Justin Anderson at [javascript protected email address] or 608-960-9853