Drug Delivery
Microbes With Reduced Adhesion Characteristics
WARF: P210080US02
Inventors: Jan Peter Van Pijkeren, Laura Alexander
The Invention
This invention from UW Madison researchers presents recombinant microorganisms and methods of using same. The recombinant microorganisms include one or more modifications that reduce the expression and/or activity of a sortase, a sortase-dependent protein, a fibronectin-binding protein, an autolysin, a surface-layer protein, an aggregation-promoting factor, and/or a collagen-binding protein. The modifications can reduce the adhesion characteristics with respect to the non-modified microbes. The recombinant microorganisms can further include a recombinant gene configured to express a biologic. The recombinant microorganisms can be used as delivery vehicles to deliver the biologics to sites such as the gastrointestinal tract.
Key Benefits
- Novel microbial delivery system
- Prevents any potential colonization of GI
- Allows for tuning of biocontainment
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847