Drug Delivery
An Adventitial Painting Modality Of Local Drug Delivery To Abate Intimal Hyperplasia
WARF: P210321US02
Inventors: Shaoqin Gong, Nisakorn Yodsanit, K. Craig Kent, Lianwang Guo, Takuro Shirasu, Bowen Wang
The Invention
The UW inventors and collaborators developed a new modality of directly “painting” drug-loaded unimolecular micelles (UM) to the adventitia thus obviating the need for a hydrogel. To render tissue adhesion, they generated amine-reactive unimolecular micelles with N-hydroxysuccinimide ester (UM-NHS) terminal groups to form stable amide bonds with the adventitia. This ensures that the active ingredient (in this case rapamycin) in the micelle stays at the damaged site rather than leaking away from the vessel and no additional tissue damage is observed.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847