Drug Discovery & Development
METHOD FOR DIFFERENTIATION OF BRAIN MURAL CELLS FROM HUMAN PLURIPOTENT STEM CELLS
WARF: P220005US02
Inventors: Eric Shusta, Benjamin Gastfriend, Sean Palecek
The Invention
UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previously disclosed protocol (P170340US02) to derive a neural crest intermediate, and subsequently overexpress the Notch3 intracellular domain in neural crest. The result is acquisition of a brain mural cell-like fate, which the inventors confirmed via increased expression of key mural cell genes.
Additional Information
For More Information About the Inventors
Tech Fields
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