Therapeutics & Vaccines
Protein Tyrosine Phosphatase 1B Inhibited Neutrophils, Neutrophil-Dendritic Cell Hybrids and Uses Thereof
WARF: P220160US03
Inventors: Igor Slukvin, Anna Huttenlocher, Morgan Giese, Ho Sun Jung, David Bennin
The Invention
UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PTP1b from iPS cells, and then utilized an existing method (P190225) to differentiate the iPSCs into neutrophils. PTP1b-/- neutrophils displayed increased cellular migration and inflammatory cytokine signaling (e.g., IL-6 and TNF) in response to bacterial stimuli, when compared with wildtype cells.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857