Drug Discovery & Development
SITE-SELECTIVE DEUTERATION OF AMINO ACIDS THROUGH DUAL PROTEIN CATALYSIS
WARF: P220181US02
Inventors: Andrew Buller, Tyler Doyon
The Invention
UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a small partner protein, DsaE, to achieve site- and enantio-selective Cα and Cβ deuteration of amino acids. In short, the method leverages the native mechanism of DsaD to selectively deuterate either at Cα when DsaD operates alone or at Cα and Cβ when DsaD and DsaE are present together. This method provides a number of advantages over traditional synthetic routes, including access to exclusively Cβ-deuterated amino acids.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847