Research Tools
GENETICALLY ENCODED SYNTHETIC REACTION-DIFFUSION SYSTEM THAT CAN GENERATE PROGRAMMABLE OSCILLATIONS, PATTERNS, AND SPATIOTEMPORAL SIGNALING CIRCUITS IN MAMMALIAN CELLS
WARF: P220268US02
Inventors: Scott Coyle, Rohith Rajasekaran
The Invention
Two UW-Madison researchers have developed a programmable reaction-diffusion system, derived from two small bacterial proteins MinD and MinE, that can be encoded into mammalian cells. In addition, the researchers have developed a frequency-domain image analysis software toolbox that allows for immediate extraction of all data within the resulting signals, which was used to identify key control parameters. Taken together, the bacterial proteins (MinD and MinE) and the control parameters were used to build specific synthetic spatiotemporal outputs. In practice, spatiotemporal signaling circuits were implemented in mammalian cells for a range of cellular processes, including precise payload delivery, universal amplification of biochemical signals, and frequency-modulation of the system via cellular data.
Tech Fields
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854