Diagnostics & Biomarkers
THE MIDBODY AND MIDBODY REMNANT ARE ASSEMBLY SITES FOR RNA AND ACTIVE TRANSLATION
WARF: P230134US02
Inventors: Ahna Skop, Sungjin Park, Smit Patel
The Invention
UW-Madison researchers have discovered that the midbody (MB) functions as an RNA-based organelle with active translation activity, which serves as a novel means of RNA-based intercellular communication. The inventors have found that the midbody (MB) is a site of ribonucleoprotein assembly and is enriched in a population of mRNAs that encode proteins involved in cell fate, oncogenesis, and pluripotency. The MB is translationally active, contains both small and large ribosomal subunits, and has both membrane-less and membrane-bound states.
Additional Information
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Tech Fields
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