Analytical Instrumentation, Methods & Materials
COMPOSITIONS AND METHODS FOR PREPARATION OF A CRYOGENIC ELECTRON MICROSCOPY SAMPLE
WARF: P230306WO01
Inventors: Ci Ji Lim
The Invention
A UW-Madison researcher proposes a new strategy that uses small, stress-response proteins to preserve fragile samples during cryo-EM SPA sample preparation. The figure below illustrates the general sample preparation system, commonly used cryo-EM grids, and ideal, typical, and rescued samples prepared with the sacrificial stress-response proteins of the present invention. The rescued samples are able to be imaged using standard cryo-EM techniques without any additional processing or handling steps.
Publications
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854
Figures
