Analytical Instrumentation, Methods & Materials
METHODS OF LABELING, PROCESSING, AND ANALYZING PROTEIN SAMPLES
WARF: P230380WO01
Inventors: Michael Sussman, Jamison Wolfer, Benjamin Minkoff
The Invention
UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a covalent labeling system called EDC/GEE (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/glycine ethyl ester), which modifies solvent accessible aspartate and glutamate residues. To advance this technique for the application of proteome-wide footprinting, the inventors have replaced the GEE with GPA (glycyl propargyl amide), to now become an EDC/GPA technique. GPA produces a more stable, single modification on a protein.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854