Analytical Instrumentation, Methods & Materials
CRYOGENIC SOFT LANDING IMPROVES STRUCTURAL PRESERVATION OF PROTEIN COMPLEXES
WARF: P240025WO01
Inventors: Joshua Coon, Michael Westphall, Timothy Grant
The Invention
UW-Madison and Morgridge researchers have designed and constructed a modified Orbitrap mass spectrometer that contains a lander attachment capable of directing an ion beam to a TEM grid cooled to liquid nitrogen temperatures (-190 ˚C). In addition to offering precise temperature regulation, their instrument also permits deposition of molecular water, allowing formation of amorphous ice thin films that are monitored by a quartz crystal microbalance in real-time. The water can be added before, during, or after particles are deposited. The system integrates a retractable ion guide so that following the cryogenic landings, the MS vacuum system can be isolated from the landing region for sample removal.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854