Therapeutics & Vaccines
IFNy AND TFNa CO-STIMULATION OF MESENCHYMAL STROMAL CELLS DERIVED FROM MINOR SALIVARY (LABIAL) GLANDS FOR THERAPEUTIC USE
WARF: P240070US02
Inventors: Sara McCoy, Jacques Galipeau
The Invention
UW-Madison researchers have developed improved methods for optimizing the characteristics of salivary gland-derived mesenchymal stromal cells (MSCs) for therapeutic administration.
The inventors have discovered two method modifications that improve the characteristics of MSCs:
- Using Collagenase AF-1 for digesting the salivary gland biopsy sample promoted greater cell proliferation in the resulting cells
- Interferon-gamma (IFNγ) is currently used to optimize the immunomodulatory and trophic potential of MSCs, as well as recovery from cryopreservation. The inventors have discovered that treating MSCs (from salivary gland, bone marrow, or adipose tissue) with a combination of IFNγ and tumor necrosis factor-alpha (TNFα) significantly improves the tissue regeneration response, by enhancing the production of R-spondin, which interacts with LGR5 receptors in cells such as epithelial progenitors, thereby promoting tissue regeneration.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857