Therapeutics & Vaccines
Inhibitors of Naegleria Fowleri
WARF: P240071US02
Inventors: Jennifer Golden, Matthew Lish, James Morris
The Invention
UW-Madison researchers in collaboration with a researcher at Clemson University have developed a chemical scaffold that potently inhibits whole Naegleria fowleri parasites in culture. They have prepared > 90 analogs with potency to EC50 = 40 nM. The compounds do not show cell toxicity in a human neuronal cell line and appear to get into the CNS.
Literature/academic efforts describe compounds with weak inhibition at best (> 30 uM) and no indication of efficacy. For reference, miltefosine, the golden child of amoeba treatment, has an
EC50 value in the 40-80 uM range.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847