Drug Delivery
MINERAL BINDING MRNA LIPID NANOPARTICLES
WARF: P240158WO01
Inventors: William Murphy, Joshua Choe
The Invention
UW-Madison researchers have developed two methods and related materials for promoting binding of mRNA LNPs to minerals. In the first, a positively charged lipid (e.g., DOTAP) is substituted/incorporated into the formulation. This addition allows for the mRNA LNP to be directly incorporated into MCMs. The second method leverages click chemistry to conjugate a hydroxyapatite (HA) – the main inorganic component of bone – targeting peptide to mRNA LNPs. These modified mRNA LNPs are able to bind HA in bone for local delivery/transfection.
Additional Information
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Tech Fields
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847